LARIS: Ligand And Receptor Interaction in Spatial transcriptomics data#
LARIS is a Python package for analyzing ligand-receptor interactions in spatial transcriptomics data. It identifies spatially-specific cell-cell communication patterns by integrating gene expression, spatial information, and cell type annotations.
Features#
Spatial LR interaction strength: Calculate ligand-receptor interaction scores using spatial adjacency information
Spatial specificity: Identify LR pairs with significant spatial variable patterns
Inference at cell type level: Compute sender-receiver cell type interaction scores
Spatial neighborhoods: Analyze interactions in the context of spatial cell type neighborhoods