PIASO: Precise Integrative Analysis of Single-cell Omics#
Current available functionalities include:
perform dimensionality reduction with GDR
integration of scRNA-seq datasets with GDR
integration of scRNA-seq data and MERFISH/Xenium data with GDR
normalization of scRNA-seq data with INFOG
selection of highly-variable genes in scRNA-seq data with INFOG
a novel gene set scoring method
run clustering on selected cluster(s)
side-by-side cell embedding plots, e.g., split by Conditions
stacked violin plots for multiple features, including genes and cell metrics
Upcoming functionalities:
preprocessing of scATAC-seq datasets
integration of scRNA-seq and scATAC-seq datasets (not relying on gene activities)
inference of cell type-specific gene regulatory networks
and others
Citation#
If PIASO is useful for your research, please consider citing Wu et al., Pyramidal neurons proportionately alter the identity and survival of specific cortical interneuron subtypes, bioRxiv (2024).