I am a senior computational scientist in Prof. Gordon Fishell's lab at Harvard Medical School and the Broad Institute of MIT and Harvard. I develop computational methods and tools, including PIASO, to analyze single-cell and spatial omics data. Previously, I finished my Ph.D. in Bioinformatics and B.S. in Bioinformatics in Institute of Genetics and Developmental Biology, Chinese Academy of Sciences and Zhejiang University, respectively.
My research focuses on unraveling the molecular mechanisms regulating cortical interneuron development and diversity. By integrating single-cell multi-omics, spatial transcriptomics, and machine learning approaches, I study how pyramidal neurons instruct interneuron identity and survival, and how cell-type-specific enhancer-AAV tools can be used to target distinct neuronal subtypes. I am particularly interested in deciphering the gene regulatory networks underlying interneuron subtype specification - how transcription factors, chromatin accessibility, and intercellular signaling converge to generate neuronal diversity. I am also fascinated by representation learning and how cell states are synergistically regulated by both endogenous and exogenous signals.
Ph.D. in Bioinformatics, 2022
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
B.S. in Bioinformatics, 2016
College of Life Sciences, Zhejiang University
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Python, R, Java, Shell, C#, JavaScript
scRNA-seq, scATAC-seq, spatial transcriptomics, Snakemake, RNA-seq, ChIP-seq, Ribo-seq
Matrix Decomposition, Network Representation Learning, Dimensionality Reduction, Data Visualization